发明名称 |
ПРИМЕНЕНИЕ ИНГИБИТОРОВ ГЛЮКОЗИДАЗЫ ДЛЯ ТЕРАПИИ МУКОВИСЦИДОЗА |
摘要 |
Glucosidase inhibitors are used to prepare medicaments for treating mucoviscidosis. ACTIVITY : CNS-Gen.; Respiratory-Gen. MECHANISM OF ACTION : Reactivator of cystic fibrosis transmembrane conductance regulator (CFTR) protein delF508 mutant. N-butyl deoxynojirimycin had an EC50 of 123 mu M for restoring iodide efflux in CF15 human lung epithelial cells (which are homozygotic for the delF508 mutation) after stimulation with forskoline and genisteine. |
申请公布号 |
RU2006119914(A) |
申请公布日期 |
2007.12.20 |
申请号 |
RU20060119914 |
申请日期 |
2004.11.05 |
申请人 |
САНТИР НАСЬОНАЛЬ ДЕ ЛЯ РЕШЕРШ СЬЕНТИФИК (FR);ЮНИВЕРСИТЕ ДЕ ПУАТЬЕ (FR) |
发明人 |
БЕКК Фредерик (FR);НОРЕ Каролин (FR) |
分类号 |
A61K31/352;A61K31/437;A61K31/4375;A61K31/445 |
主分类号 |
A61K31/352 |
代理机构 |
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