SPECIFIC BINDING MEMBERS FOR HUMAN TRANSFORMING GROWTH FACTOR BETA; MATERIALS AND METHODS

摘要

Specific binding members comprising human antibody antigen binding domains specific for human transforming growth factor beta (TGF.beta.) bind specifically isoforms TGF.beta.2 and TGF.beta.1 or both, preferentially compared with TGF.beta.3. Specific binding members may be isolated and utilised in the treatment of disease, particularly fibrotic disease and also immune/inflammatory diseases. Therapeutic utility is demonstrated using in vitro and in vivo models. Full sequence and binding information is provided, including epitope sequence information for a particularly advantageous specific binding member which binds the acti ve form of TGF,82, neutralising its activity, but does not bind the latent form.