发明名称 |
NOVEL POLYPEPTIDES FOR PROMOTING CELL ATTACHMENT |
摘要 |
<P>PROBLEM TO BE SOLVED: To provide a polypeptide which inhibits the binding of fibronectin to GPIIb-IIIa. <P>SOLUTION: Novel polypeptides derived from human fibronectin, and fusion proteins containing those peptide sequences are described which define a receptor binding site on fibronectin that binds to the platelet receptor glycoprotein GPIIb-IIIa expressed by cells. The receptor binding site of human fibronectin includes at least fibronectin amino acid residues 1410-1436. The polypeptides facilitate attachment of cells to substrates either alone or in conjunction with RGD-containing peptides. Vectors preparing the fusion proteins and antibodies are also described. Methods for promoting cell attachment and for inhibiting cell adhesion are also described. <P>COPYRIGHT: (C)2008,JPO&INPIT |
申请公布号 |
JP2007312788(A) |
申请公布日期 |
2007.12.06 |
申请号 |
JP20070193288 |
申请日期 |
2007.07.25 |
申请人 |
SCRIPPS RES INST:THE |
发明人 |
GINSBERG MARK H;PLOW EDWARD F;BOWDITCH RONALD |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61L27/22;A61P7/02;C07K14/47;C07K14/705;C07K14/75;C07K14/78;C07K16/00;C07K16/18;C07K19/00;C12N5/00;C12N5/06;C12N11/00;C12P21/02;C12P21/08;C12R1/91 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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