发明名称 |
CONFORMATION SPECIFIC ANTIBODIES |
摘要 |
The disclosure provides, inter alia, binding proteins (e.g., antibodies) that bind to an integrin in an activated conformation, e.g., activated LFA-1 ("aLFA-1"), e.g., relative to a non-activated conformation of LFA-1. In one embodiment, the binding proteins inhibit at least one function of an aLFA-1, e.g., inhibit a binding interaction between aLFA-1 and a cognate ligand of aLFA-1, e.g., an ICAM protein. The binding proteins can be used to treat or prevent an inflammatory disorder or other disorder. |
申请公布号 |
WO2005079515(A3) |
申请公布日期 |
2007.12.06 |
申请号 |
WO2005US05361 |
申请日期 |
2005.02.22 |
申请人 |
THE CBR INSTITUTE FOR BIOMEDICAL RESEARCH, INC.;DYAX CORP.;COHEN, EDWARD, H.;RONDON, ISAAC, J.;SPRINGER, TIMOTHY, A.;SHIMAOKA, MOTOMU |
发明人 |
COHEN, EDWARD, H.;RONDON, ISAAC, J.;SPRINGER, TIMOTHY, A.;SHIMAOKA, MOTOMU |
分类号 |
A61K39/395;C07K16/00;C07K16/28;C07K16/46 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|