POLYCYSTIC KIDNEY DISEASE-RELATED GENE AND USE THEREOF

摘要

A major gene of a pc mutant of a Japanese Medaka fish (Oryzias latipes) has been identified. Based on this finding, use of the gene is provided. A gene responsible for polycystic kidney in a Japanese Medaka fish is identified in the chromosomal region of the fish by performing a positional cloning on a pc mutant of the fish. The pc gene is a transcription factor having five C2H2-type zind finger regions, and is considered to be a gene homologous to human Gli-similar 3 (Glis3) gene since it shows a high homology in the zinc finger regions.