| 摘要 |
Non-peptide compounds are provided to inhibit activity of bradykinin, chronic neuropathic pain and inflammatory pain, so that they are useful for prevention and treatment of disease caused by bradykinin such as pain. The non-peptide compounds represented by the formula(1) or pharmaceutically acceptable salts thereof are provided, wherein R1 and R2 are each independently hydrogen; C1-C4 alkyl; C1-C4 alkoxy; C3-C10 cycloalkyl; C6-C20 aryl and C5-C20 heteroaryl which are optionally substituted by at least one substituent selected from group consisting of C1-C4 alkyl, C1-C4 alkoxy or halogen; C1-C4 alkyl substituted by C6-C20 aryl which is optionally substituted by at least one substituent selected from group consisting of C1-C4 alkyl, C1-C4 alkoxy or halogen; and C1-C4 alkyl substituted by C5-C20 hetero aryl which is optionally substituted by at least one substituent selected from group consisting of C1-C4 alkyl, C1-C4 alkoxy or halogen; X is C1-C4 alkylenyl optionally substituted by C1-C4 alkyl, C1-C4 alkoxy or halogen; C2-C6 alkenylenyl optionally substituted by C1-C4 alkyl, C1-C4 alkoxy or halogen, -CH2YCH2- or -CH2CH2Y-; Y is O, S or NR3; R3 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, halogen or -COO-C1-C4 alkyl; Z and Z' are each independently hydrogen, hydroxy or halogen; and n is an integer from 1 to 3.
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