| 摘要 |
PROBLEM TO BE SOLVED: To provide chewable solid unit dosage forms. SOLUTION: The present invention relates to methods and an oral care composition for topical, oral administration in a human or other animal comprising: a. from about 1% to about 40%, by weight of the composition, of a retentive agent selected from the group consisting of water-soluble hydrophilic gums, water-soluble hydrophilic polymers, and mixtures thereof, the retentive agent having the property of hydrating upon exposure to water or saliva resulting in the composition forming an intact hydrated mass to provide a retention index of about 1 to about 4; and b. a safe and effective amount of a topical, oral care carrier; wherein the composition comprises less than about 65 wt.% of water-insoluble particulates. The present invention further relates to an oral care dentifrice composition comprising: a. from about 30% to about 65%, by weight of the composition, of a water insoluble, particulate retentive agent having a water solubility of less than about 1 g/30 g at 25°C; b. a safe and effective amount of an oral care active substance; c. a safe and effective amount of a surfactant; d. a safe and effective amount of a buffer. COPYRIGHT: (C)2008,JPO&INPIT
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