发明名称 |
COMBINATION THERAPY OF HEDGEHOG INHIBITORS, RADIATION AND CHEMOTHERAPEUTIC AGENTS |
摘要 |
The present invention relates to therapeutic combinations and methods of inhibiting the proliferation of cancerous cells, the abnormal growth of cells, and tumor cell growth using the combination of a hedgehog inhibitor with chemotherapy and/or radiation therapy. The present invention also relates to methods of enhancing the antiproliferative effect of chemotherapy and/or radiation therapy in a mammalian cancer patient undergoing either chemotherapy or radiation or a combination of radiation and chemotherapy by co-administering a therapeutically amount of a hedgehog inhibitor, concurrently or sequentially, with the chemotherapy and/or radiation therapy.
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申请公布号 |
US2007281040(A1) |
申请公布日期 |
2007.12.06 |
申请号 |
US20050576310 |
申请日期 |
2005.09.30 |
申请人 |
THE UNIVERSITY OF CHICAGO |
发明人 |
WEICHSELBAUM RALPH R.;SHAFAEE ZAHRA;DU WEI |
分类号 |
A61K31/4355;A61K31/337;A61K31/56;A61K31/70;A61K33/24;A61N5/10;A61P35/00 |
主分类号 |
A61K31/4355 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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