发明名称 |
Combination of Insulin and Ascorbate to Enhance Wound Healing |
摘要 |
Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican and keratocan. Insulin plus ascorbate, however, stimulates the synthesis of collagen and increased the accumulation of these proteoglycans. The accumulation of PGDS, a KSPG that does not interact with collagen, is not affected by ascorbate. Only the collagen made in the presence of ascorbate was pepsin resistant. EDB overrode the effects of ascorbate on pepsin resistance and proteoglycan accumulation.
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申请公布号 |
US2007281882(A1) |
申请公布日期 |
2007.12.06 |
申请号 |
US20070758080 |
申请日期 |
2007.06.05 |
申请人 |
UNIVERSITY OF SOUTH FLORIDA |
发明人 |
MUSSELMANN KURT;HASSELL JOHN R.;KANE BRAD;ALEXANDROU BRIDGETTE |
分类号 |
A61K38/28;A61K31/375;A61K31/665 |
主分类号 |
A61K38/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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