摘要 |
Novel uses for anti-thymocyte globulin (ATG, e.g., Thymoglobulin®) and related compositions are described. In one aspect, ATG and, optionally, TGF-ß are used for in vitro generation of regulatory T cells, which are useful for cell therapy of immune-mediated conditions. In another aspect, ATG is directly administered to a subject at a low dose (e.g., less than 1 mg/kg per day) to treat an immune-mediated condition. The immune-mediated conditions include, for example, transplant rejection, graft-versus-host disease, and autoimmune diseases. |
申请人 |
GENZYME CORPORATION;THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;NAJAFIAN, NADER;SAYEGH, MOHAMED, H.;RUZEK, MELANIE;SHANKARA, SRINIVAS;WILLIAMS, JOHN;KAPLAN, JOHANNE;MCPHERSON, JOHN, M. |
发明人 |
NAJAFIAN, NADER;SAYEGH, MOHAMED, H.;RUZEK, MELANIE;SHANKARA, SRINIVAS;WILLIAMS, JOHN;KAPLAN, JOHANNE;MCPHERSON, JOHN, M. |