COMPOSITIONS AND METHODS FOR THE DELIVERY OF OXYGEN

摘要

H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O₂ delivery. The engineered H-NOX proteins comprise mutations that impart altered O₂ or NO ligand-binding relative to the corresponding wild-type H-NOX domain, and are operative as physiologically compatible mammalian blood O₂ gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition for which delivery of O₂ is beneficial.