| 摘要 |
Radiation has been used for many years to treat cancer patients. In the case of ionizing electromagnetic radiation, the incidental, extra dose to tissues surrounding the tumor is significant. The aim of this invention is to provide compounds and methods to enhance the absorbed radiation dose ratio, or other therapeutic compounds, in tumors verses normal tissue. The system concentrates contrast agents with high atomic number elements preferentially at the site of the tumor prior to administering radiotherapy, or preferentially concentrates other therapeutic compounds in the abnormal region. The agents are concentrated in a pathologic lesion following systemic or direct administration. Interaction of the ionizing radiation with the coupled compounds of this invention results in a significantly higher radiation dose to the tumor compared to surrounding tissues. The result is greater therapeutic efficacy with fewer side effects following treatment with low-energy radiation, or other agents. These compounds permit diagnostic uses in combination with the therapeutic use. |
