TGF-BETA PHARMACEUTICAL COMPOSITIONS

摘要

This invention relates to pharmaceutical compositions comprising TGFbeta, and in particular to liquid compositions comprising TGFbeta wherein the pH of the composition is at or below 3.7. In one form, the invention is an article of manufacture comprising a vial, cartridge or vaginal applicator and a pharmaceutical composition according to the claims of this application. In another form, the invention is a method of treating an infertility condition by administering to a prospective mother a pharmaceutical composition according to the claims of this application. In another form, the invention is a method of treating an infertility condition, by inducing immune tolerance to a paternal antigen in a prospective mammalian mother lacking said immune tolerance, said method comprising exposing a mucosal surface of said prospective mother to a pharmaceutical composition of this application and semen or an MHC Class I antigen of a prospective father capable of eliciting a Th-1 response.