| 摘要 |
The present invention provides a composition of amino acid sequences including minimal CTL epitopes identified in the viral proteins Gag, Pol, Env, Vif, Vpr, and Vpu and variants hereof. The composition is contemplated as a therapeutic vaccine, in particular a tailor-made therapeutic vaccine. Further, the invention provides a nucleic acid molecule comprising a sequence of nucleic acids encoding amino acids according to the invention. Also provided are the use of said composition in medicine and for the manufacture of a medicament for in the manufacture of a medicament for the prevention and/or treatment of human immunodeficiency virus infections, a method for preparing the composition and a method of treating an individual being infected with a human immunodeficiency virus or reducing the risk of infection with a human immunodeficiency virus. |
