METHODS FOR INTERVENTIONS AND TESTING FOR CALORIC RESTRICTION (CR) MIMETICS

摘要

Methods and systems for monitoring interventions and/or a subject, such as a human patient. One exemplary embodiment of a method includes measuring at least one biological parameter of a subject, determining a biological state from the measuring, administering (after the measuring) an intervention which includes a caloric restriction (CR) mimetic to the subject and measuring, after the administering, the at least one biological parameter and determining a later biological state from the measuring after the administering. Methods for treating neurological diseases and for testing Caloric Restriction (CR) mimetics or CR mimetic candidates. In one exemplary method, a CR mimetic candidate is administered to a transgenic animal and the effects of the administering are determined; the transgenic animal includes an added gene from another type of animal or a modified gene which is designed to produce a disease or ailment of the another type of animal, and the method seeks to determine whether the CR mimetic candidate improves the disease or ailment. Methods relating to neurological disease and other methods relating to CR mimetic testing are also described.