COMPOSITIONS AND METHODS FOR THE DELIVERY OF NITRIC OXIDE
摘要
H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas NO delivery. The engineered H-NOX proteins comprise mutations that impart altered NO or O<SUB>2 </SUB>ligand-binding relative to the corresponding wild-type H-NOX domain, and are operative as physiologically compatible mammalian blood NO gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition for which delivery of NO is beneficial.
申请公布号
WO2007139767(A2)
申请公布日期
2007.12.06
申请号
WO2007US12133
申请日期
2007.05.21
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;CARY, STEPHEN, P., L.;BOON, ELIZABETH, M.;WINGER, JONATHAN, A.;MARLETTA, MICHAEL, A.
发明人
CARY, STEPHEN, P., L.;BOON, ELIZABETH, M.;WINGER, JONATHAN, A.;MARLETTA, MICHAEL, A.