BIOADHESIVE NANOPARTICLES FOR ADMINISTRATION OF BIOLOGICALLY ACTIVE MOLECULES

摘要

The invention relates to nanoparticles for the administration of biologically active molecules comprising a biodegradable polymer, preferably the copolymer of methyl vinyl ether and maleic anhydride (MVE/MA), and thiamine. Such nanoparticles are simply produced having excellent characteristics of bioadhesion, size and zeta potential, rendering them suitable for the administration of active molecules. The procedure of obtainment of such nanoparticles is realised by simple incubation for a short period of time, the nanoparticles being preformed in an aqueous medium. The biologically active molecule may be incorporated during the process of formation of the nanoparticles by desolvation or through modification with thiamine. By oral route said nanoparticles develop bioadhesive interactions with the gastrointestinal mucous membrane, including the lymphoid tissue associated with mucous membranes (Peyer's patches), and are therefore useful for increasing the oral bioavailability of various drugs or inducing immune responses in mucous membranes. Thus when such nanoparticles contain an antigen within the matrix thereof the resultant mixture is capable of inducing strong immune responses to the encapsulated antigen. Such stimulating effect on immune response is useful in vaccination and immunotherapy.