MONONUCLEOSIDE PHOSPHONATE COMPOUNDS

摘要

The present invention relates to a mononucleoside phosphonate compound in which the nature of the linkage between the ribosyl or carbocyclic residue and the phosphorous atom of a mononucleotide is modified to include alkylene groups, which improve the stability of the compound. These mononucleoside phosphonate compounds optionally have a degradation-resistant substituent attached on the terminal phosphate. By modification of the linkage and the attachment of the degradation-resistant substituent, the stability of the mononucleoside phosphonate compound significantly improves. The mononucleoside phosphonate compounds of the present invention are useful in preventing and treating diseases or disorders associated with platelet aggregation.