NUCLEOTIDE AND PROTEIN SEQUENCES OF COC GENES AND METHODS BASED THEREON

摘要

The present invention provides nucleotide sequences of a neural induction gene, Coco, and amino acid sequences of encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. Coco is an inhibitor of TGF-ß, BMP, and Wnt signal transduction. In a specific embodiment, the Coco protein is a human protein. Antibodies to Coco, its derivatives and analogs, are additionally provided. Methods of production of the Coco proteins, derivatives and analogs, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided.