A1 ADENOSINE RECEPTOR ANTAGONISTS

摘要

wherein R₃ is Alk₁₄ArR₁₆, and wherein Alk₁₄ is C_1-8 straight or branched alkylene or alkenylene. The present invention provides novel adenosine receptor antagonists, more particularly, A₁ adenosine receptor antagonists of formula (I). Pharmaceutical compositions comprising an A₁ adenosine receptor antagonist of formula (I) and a pharmaceutically acceptable carrier are further provided. Compositions also include diagnostic assay-type probes comprising a novel A₁ adenosine receptor antagonist of formula (I) that is labeled or conjugated with radioactive or non-radioactive material. Methods for treating A₁ adenosine receptor related disorders comprising administering an A₁ adenosine receptor antagonist of formula (I) are also disclosed. The novel A₁ adenosine receptor antagonist compositions of formula (I) find further use in diagnostic and imaging methods.