| 发明名称 |
COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS |
| 摘要 |
<p>The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.</p> |
| 申请公布号 |
WO2007140117(A1) |
申请公布日期 |
2007.12.06 |
| 申请号 |
WO2007US68987 |
申请日期 |
2007.05.15 |
| 申请人 |
IRM LLC;TULLY, DAVID, C.;CHATTERJEE, ARNAB, K.;PETRASSI, HANK, MICHAEL, JAMES;BURSULAYA, BADRY;SPRAGGON, GLEN |
发明人 |
TULLY, DAVID, C.;CHATTERJEE, ARNAB, K.;PETRASSI, HANK, MICHAEL, JAMES;BURSULAYA, BADRY;SPRAGGON, GLEN |
| 分类号 |
C07K5/06;A61K38/55;A61P11/00;A61P11/06;A61P11/10;C07K5/08 |
主分类号 |
C07K5/06 |
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