ANTIVIRAL NUCLEOSIDE DERIVATIVES

摘要

The present invention relates to nucleoside derivatives for use in the treatment or prophylaxis of hepatitis C virus infections. In particular, the present invention relates to known 2'-deoxy-2'-fluoro nucleoside derivatives and their use as inhibitors of hepatitis C virus (HCV) RNA replication and pharmaceutical compositions of such compounds. The compounds of this inventi on have potential use as therapeutic agents for the treatment of HCV infections . The present invention describes the use of 2'-deoxy-2'-fluoro nucleoside derivatives of formula I wherein R1 is hydrogen or phosphate and B signifies a 1-pyrimidinyl or 9-purinyl residue of formulae B1, B2, B3 and of pharmaceutically acceptable salts thereof for the treatment of diseases mediated by the hepatitis C virus (HCV) or for the preparation of medicament s for such treatment.