发明名称 CD-10 activated prodrug compounds
摘要 The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Methods of treatment using the prodrug and methods of designing a prodrug are also disclosed.
申请公布号 US7304032(B2) 申请公布日期 2007.12.04
申请号 US20040022341 申请日期 2004.12.22
申请人 MEDAREX, INC. 发明人 BEBBINGTON CHRISTOPHER R.;NIEDER MATTHEW H.;CARDARELLI PINA M.;GANGWAR SANJEEV;PICKFORD LESLEY B.;PAN CHIN
分类号 A61K38/02;A61K31/704;A61K38/06;A61K38/07;A61K38/08;A61K45/00;A61K47/48;A61K49/00;A61P35/00;A61P35/02;A61P35/04;A61P43/00;C07K5/06;C07K5/083;G01N33/68 主分类号 A61K38/02
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