| 发明名称 |
Screening method for candidate drugs |
| 摘要 |
The present invention relates to methods for screening molecules and methods to detect protein-protein interactions and means used therein. More specifically, the present invention relates to methods for screening candidate drugs for treating or detecting MIF (macrophage migration inhibitor factor) related diseases. In certain aspects, the present invention involves detecting MIF/Jab1 (c-Jun activation domain binding protein) interactions as a basis for modulating cellular regulatory pathways and for identifying candidate drugs for MIF-related diseases. The invention also provides methods for the identification of molecules which dissociate or prevent interaction or binding between MIF and Jab1.
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| 申请公布号 |
US7303885(B1) |
申请公布日期 |
2007.12.04 |
| 申请号 |
US20000148496 |
申请日期 |
2000.11.02 |
| 申请人 |
FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V. |
发明人 |
BRUNNER HERWIG;BERNHAGEN JUERGEN;KLEEMANN ROBERT;MISCHKE RALF;KAPURNIOTU AFRODITI |
| 分类号 |
C07K1/22;G01N33/50;A61K31/7088;A61K35/76;A61K38/00;A61K39/395;A61K48/00;A61P3/04;A61P3/10;A61P11/16;A61P13/04;A61P13/08;A61P13/12;A61P17/00;A61P19/02;A61P25/00;A61P25/16;A61P27/14;A61P27/16;A61P29/00;A61P31/04;A61P35/00;A61P37/02;A61P37/06;A61P37/08;A61P43/00;C07K14/47;C07K14/52;C07K16/18;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12P21/08;C12Q1/02;C12Q1/68;G01N33/15;G01N33/53;G01N33/566;G01N33/68 |
主分类号 |
C07K1/22 |
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