发明名称 |
Mule: Mcl-1 ubiquitination ligase E3 |
摘要 |
A HECT-domain containing E3 ubiquitin ligase that mediates the polyubiquitination of Mcl-1, named Mule for Mcl-1 ubiquitin ligase E3, is described. Methods and compositions for modulating functional interaction between Mcl-1 and Mule protein and Mcl-1 mediated apoptosis are described. Diagnostic and prognostic methods based on Mule expression in patient cells are also described.
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申请公布号 |
US7303887(B2) |
申请公布日期 |
2007.12.04 |
申请号 |
US20050132977 |
申请日期 |
2005.05.18 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
WANG XIAODONG;ZHONG QING;GAO WENHUA;DU FENGHE |
分类号 |
G01N33/53;C07K5/10 |
主分类号 |
G01N33/53 |
代理机构 |
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