| 摘要 |
<p>The present invention provides a highly stereoselective, simple and economical glycosylation process for preparation of beta-anomer enriched 2<SUP>1</SUP>-deoxy-2<SUP>1</SUP>,2<SUP>1</SUP>-D-ribofuranosyl difluoronucleosides of formula (II), and physiologically acceptable salts thereof, in particular, the beta-enriched anomer of gemcitabine hydrochloride of formula (IIb) in purity of >99% is provided through utilization of a novel trichloroacetimidate of formula (I).</p> |
