发明名称 |
PROCESS FOR PREPARATION OF BICALUTAMIDE |
摘要 |
<p>The present invention discloses a process for the synthesis of N-[4-Cyano-3-(trifluoromethyl) phenyl]-3-[(4-fluorophenyl) sulphonyl]-2-hydroxy-2-methyl propanamide (Form I). The invention discloses a reagent for oxidation of N-[4-Cyano-3-(trifluoromethyl) phenyl]-3-[(4-fluorophenyl) thio]-2-hydroxy-2-methyl propanamide to N-[4-Cyano-3-(trifluoromethyl) phenyl]-3-[(4-fluorophenyl) sulphonyl]-2-hydroxy-2-methyl propanamide. More particularly, the invention discloses a method of purification of N-[4-Cyano-3-(trifluoromethyl) phenyl]-3-[(4-fluorophenyl) sulphonyl]-2-hydroxy-2-methyl propanamide in a mixture of methylethyl ketone and hexane giving form (I). This form (I) is useful as an active pharmaceutical and has antiandrogenic activity.</p> |
申请公布号 |
KR20070114343(A) |
申请公布日期 |
2007.12.03 |
申请号 |
KR20077003254 |
申请日期 |
2007.02.09 |
申请人 |
USV LIMITED |
发明人 |
TARUR VENKATASUBRAMANIAN RADHAKRISHNAN;KADAM SURESH MAHADEV;JOSHI ANIL PURUSHOTTAM;GAVHANE SACHIN BABAN |
分类号 |
C07C315/02;C07C315/06;C07D317/46 |
主分类号 |
C07C315/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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