CRYSTALLINE [R-(R*R*)] - 2 - (4 - FLUOROPHENYL) - ??, Ó¬á - DELTA-DIHYDROXY - 5 - (1 - METHYLETHYL) - 3 - PHENYL - 4 - (PHENYLAMINO) CARBONYL] - 1H - PYRROLE - 1 - HEPTANOIC ACID HEMI CALCIUM SALT (ATORVASTATIN)HYDRATE

摘要

There are described novel crystalline forms of ÄR-(R*,R*)Ü-2-(4-fluorophenyl)- beta , delta -dihydroxy-5-(1-methylethyl)-3-phenyl-4-Ä(phenylamino)carbonylÜ-1H-pyr role-l-heptanoic acid hemi calcium salt designated Form II and Form IV which are characterized by their X-ray powder diffraction and/or solid state NMR, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia and hypercholesterolemia.