PREPARATION OF AMINOPYRIMIDINE COMPOUNDS

摘要

A 2-(N-METHYL-N-METHANESULFONYLAMINO) PYRIMIDINE COMPOUND OF THE FORMULA (3) : [“R” IS A HYDROCARBYL GROUP], IS PREPARED BY THE STEPS OF: (I) REACTING AN ISOBUTYRYLACETATE ESTER WITH 4-FLUOROBENZALDEHYDE AND UREA IN THE PRESENCE OF A PROTONIC COMPOUND AND A METAL SALT; (II) OXIDIZING THE REACTION PRODUCT OF THE STEP (I); (III) REACTING THE OXIDATION PRODUCT OF THE STEP (II) WITH AN ORGANIC SULFONYL HALIDE OR AN ORGANIC SULFONYL ANHYDRIDE; AND (IV) REACTING THE REACTION PRODUCT OF THE STEP (III) WITH N-METHYL-N-METHANESULFONAMIDE.