ENZYMATIC KINETIC RESOLUTION OF AN INTERMEDIATE USEFUL FOR PREPARING SUBSTITUTED TRICYCLICS

摘要

THE INVENTION RELATES TO A PROCESS FOR PREPARING A SUBSTITUTED (6, 11-DIHYDRO-5H-BENZO [5,6] CYCLOHEPTA [1,2-B] PYRIDIN-11-YL) PIPERIDINE COMPOUND OF THE FORMULA (+)-I(FORMULA 1)WHEREIN:R, R1,R2, R3 AND R4 ARE INDEPENDENTLY SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, HALO, C1-C6 ALKYL, AMINO, -OCH3, -OCF3 AND CF3, AND THE DOTTED LINE REPRESENTS AN OPTIONAL DOUBLE BOND; COMPRISING; ENZYMATICALLY CATALYZING THE ACYLATION OF COMPOUND OF THE FORMULA (±)- II(FORMULA 2)WHEREIN THE VARIABLES ARE AS DEFINED ABOVE, AND HYDROLYSING THE PRODUCT TO OBTAIN (+)-I