1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors and pharmaceutical compositions containing them

摘要

Disclosed herein are imidazole derivatives of the formula (I) in which R1, R2, R3, R4, R5, R6 and n are as defined in the specification. Pharmaceutical compositions containing these derivatives, and to the uses thereof are also disclosed. By virtue of their capability to inhibit aromatase, and thus to exhaust all sources of endogenous estrogens, the compounds of formula (I) can be used alone or in combination with other active ingredients for the treatment or the prevention of any estrogen-dependent disorder or for the management of estrogen-regulated reproductive functions, in humans as well as in wild or domestic animals.