摘要 |
THERE IS PROVIDED PHARMACEUTICALLY-ACCEPTABLE ACID ADDITION SALTS OF COMPOUNDS OF FORMULA I,WHEREIN R1 REPRESENTS C1-2 ALKYL SUBSTITUTED BY ONE OR MORE FLUORO SUBSTITUENTS; R2 REPRESENTS C1-2 ALKYL; AND N REPRESENTS 0, 1 OR 2, WHICH SALTS ARE USEFUL AS PRODRUGS OF COMPETITIVE INHIBITORS OF TRYPSIN-LIKE PROTEASES, SUCH AS THROMBIN, AND THUS, IN PARTICULAR, IN THE TREATMENT OF CONDITIONS WHERE INHIBITION OF THROMBIN IS REQUIRED (E.G. THROMBOSIS) OR AS ANTICOAGULANTS.
|