发明名称 |
COMPOSITIONS FOR AFFECTING WEIGHT LOSS |
摘要 |
Disclosed are compositions for affecting weight loss comprising a first compound and a second compound, where the first compound is an opioid antagonist and the second compound causes increased agonism of a melanocortin 3 receptor (MC3-R) or a melanocortin 4 receptor (MC4-R) compared to normal physiological conditions. Also disclosed are methods of affecting weight loss, increasing energy expenditure, increasing satiety in an individual, or suppressing the appetite of an individual, comprising identifying an individual in need thereof and treating that individual to antagonize opioid receptor activity and to enhance alpha-MSH activity.
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申请公布号 |
US2007275970(A1) |
申请公布日期 |
2007.11.29 |
申请号 |
US20070779008 |
申请日期 |
2007.07.17 |
申请人 |
OREXIGEN THERAPEUTICS, INC. |
发明人 |
WEBER ECKARD;COWLEY MICHAEL A. |
分类号 |
A61K31/443;A61K31/135;A61K31/138;A61K31/4525;A61K31/485;A61P3/04 |
主分类号 |
A61K31/443 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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