发明名称 |
CASPASE-9:BIR3 DOMAIN OF XIAP COMPLEXES AND METHODS OF USE |
摘要 |
The present invention provides polypeptides and specific binding agents that modify the activity of an initiator caspase involved in apoptosis, caspase-9. The polypeptides include the third baculoviral IAP repeat (BIR3) of an IAP and form a heterodimer complex with caspase-9. Nucleic acid molecules including expression vectors encoding the polypeptides and variants thereof as well as variants of caspase-9 are provided. Such polypeptide and nucleic acid molecules may be used for modifying apoptosis. |
申请公布号 |
WO2004066958(A3) |
申请公布日期 |
2007.11.29 |
申请号 |
WO2004US02730 |
申请日期 |
2004.01.30 |
申请人 |
THE TRUSTEES OF PRINCETON UNIVERSITY;SHI, YIGONG |
发明人 |
SHI, YIGONG |
分类号 |
C12N9/50;A61F2/00;A61K;A61K9/50;A61K38/00;A61K38/17;A61K49/18;A61L27/54;A61L29/16;A61L31/16;A61N1/00;C07H21/04;C07K1/00;C07K14/47;C12N9/99;C12N15/09;C12Q1/68 |
主分类号 |
C12N9/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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