| 摘要 |
Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia. |
| 申请人 |
MERCK & CO., INC.;GE, MIN;HE, JIAFANG;LAU, FIONA WAI YU;LIANG, GUI-BAI;LIN, SONGNIAN;LIU, WEIGUO;WALSH, SHAWN, P.;YANG, LIHU |
发明人 |
GE, MIN;HE, JIAFANG;LAU, FIONA WAI YU;LIANG, GUI-BAI;LIN, SONGNIAN;LIU, WEIGUO;WALSH, SHAWN, P.;YANG, LIHU |
