发明名称 |
PEPTIDE SUBSTANCE ENHANCING CAPILLARIES RESISTANCE, PHARMACEUTICAL COMPOSITION ON ITS BASE AND METHOD OF ITS APPLICATION |
摘要 |
<p>The invention is related to the medicinal means of correction of metabolic vascular syndrome and diseases, associated with disordered vascular wall permeability and capillaries fragility, and can be used as a means of enhancing capillaries resistance. There is proposed a peptide lysyl-glutamyl-asparagine acid of the general formula H-Lys-Glu-Asp-OH sequence 1 [SEQ ID NO:1], revealing biological activity and capable of enhancing capillaries resistance. There is also proposed a pharmaceutical composition enhancing capillaries resistance, containing effective amount of peptide lysyl-glutamyl-asparagine acid of the general formula H-Lys-Glu-Asp-OH sequence 1 [SEQ ID NO:1] as its active base and pharmaceutically acceptable carrier. This pharmaceutical composition is in form for parenteral administration. There is proposed a method for prevention and/or treatment of disorders of microcirculation in organs and tissues, consisting in the administration to a patient of the pharmaceutical composition, containing peptide lysyl-glutamyl-asparagine acid of the general formula H-Lys-Glu-Asp-OH sequence 1 [SEQ ID NO:1] in the dose of 0,01 - 100 µg/kg of body weight at least once a day during a period necessary for attaining the therapeutic effect, such administration being performed parenterally.</p> |
申请公布号 |
WO2007136294(A1) |
申请公布日期 |
2007.11.29 |
申请号 |
WO2006RU00652 |
申请日期 |
2006.12.04 |
申请人 |
OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTYU "SIA PEPTIDES";KHAVINSON, VLADIMIR KHATSKELEVICH;GRIGORIEV, EVGENY IOSIFOVICH;MALININ, VLADIMIR VICTOROVICH;RYZHAK, GALINA ANATOLIEVNA |
发明人 |
KHAVINSON, VLADIMIR KHATSKELEVICH;GRIGORIEV, EVGENY IOSIFOVICH;MALININ, VLADIMIR VICTOROVICH;RYZHAK, GALINA ANATOLIEVNA |
分类号 |
C07K5/08;A61K38/06 |
主分类号 |
C07K5/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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