发明名称 |
Immortalization of Mammalian Cells |
摘要 |
Genomic instability in T-antigen expressing cells can be overcome by modifying the gene expressing T-antigen so that it lacks Bub1 binding. Stable cell lines can be produced by incorporation of the modified T-antigen gene, preferably together with the catalytic sub-unit of the telomerase construct.
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申请公布号 |
US2007274969(A1) |
申请公布日期 |
2007.11.29 |
申请号 |
US20040570126 |
申请日期 |
2004.09.10 |
申请人 |
ROBERTS THOMAS;GJOERUP OLE;JAT PARMJIT;COTSIKI MARINA |
发明人 |
ROBERTS THOMAS;GJOERUP OLE;JAT PARMJIT;COTSIKI MARINA |
分类号 |
A61K48/00;A61K35/00;A61K35/12;A61P25/16;A61P25/28;C07H21/04;C07K14/025;C12N5/08;C12N5/10 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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