发明名称 SPECIFIC BINDING PROTEIN AND USE THEREOF
摘要 <P>PROBLEM TO BE SOLVED: To provide a specific binding member, particularly antibody and active fragment thereof, which recognizes an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. <P>SOLUTION: The present invention provides an isolated specific binding member, particularly the isolated specific binding member which recognizes an EGFR epitope which does not demonstrate any amino acid sequence alterations or substitutions from normal EGFR and which is found in tumorigenic, hyper proliferative or abnormal cells and is not detectable in normal cells. <P>COPYRIGHT: (C)2008,JPO&INPIT
申请公布号 JP2007306933(A) 申请公布日期 2007.11.29
申请号 JP20070177834 申请日期 2007.07.05
申请人 LUDWIG INST FOR CANCER RESEARCH 发明人 OLD LLOYD J;JOHNS TERRANCE GRANT;PANOUSIS CON;SCOTT ANDREW MARK;RENNER CHRISTOPH;RITTER GERD;JUNGBLUTH ACHIM;STOCKERT ELISABETH;COLLINS PETER;CAVENEE WEBSTER K;HUANG HUEI-JEN;BURGESS ANTHONY WILKS;NICE EDOUARD COLLINS
分类号 C12N15/09;G01N33/50;A61K39/00;A61K39/395;A61K45/00;A61K51/00;A61P35/00;C07K16/28;C07K16/32;C07K16/46;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/02;C12P21/08;G01N33/15;G01N33/53;G01N33/566;G01N33/574 主分类号 C12N15/09
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