发明名称 CXCR4 modulators
摘要 The present invention is directed to novel compounds and pharmaceutical compositions that inhibit the binding of the SDF-1 chemokine to the chemokine receptor CXCR4 and/or the binding of the SDF-1 or I-TAC chemokines to the chemokine receptor CCXCKR2 (CXCR7). These compounds are useful in preventing tumor cell proliferation, tumor formation, metastasis, inflammatory diseases, treatment of HIV infectivity, treatment of stem cell differentiation and mobilization disorders, and ocular disorders.
申请公布号 US2007275965(A1) 申请公布日期 2007.11.29
申请号 US20070731695 申请日期 2007.03.30
申请人 CHEMOCENTRYX, INC. 发明人 THOMAS WILLIAM D.;LELETI MANMOHAN R.;PENNELL ANDREW M.
分类号 A61K31/403;A61K31/416;A61K31/4184;A61K31/4192;A61K31/421;A61K31/435;A61K31/437;A61K31/4439;A61K31/444;A61K31/497;A61K31/5377;A61P27/02;A61P29/00;A61P35/00;A61P35/04;C07D209/02;C07D209/10;C07D209/56;C07D209/82;C07D215/06;C07D231/56;C07D235/08;C07D249/04;C07D263/58;C07D295/02;C07D401/02;C07D471/04 主分类号 A61K31/403
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