A METHOD FOR INHIBITING ANGIOGENESIS USING DKK1 AND COMPOSITION COMPRISING THE SAME

摘要

The present invention relates to a method for inhibiting angiogenesis using by DKK1 protein and the composition comprising the same. The DKK1 protein and DKK1 protein-encoding DNA of the present invention shows potent inhibitory effect on the tube formation on HUVEC, sprouting of arterial circle tissues and vascular development of mice embryo. Therefore, it can be used as the therapeutics or health care food for treating and preventing diseases caused by the angiogenesis.