PYRIMIDINE LOW MOLECULAR WEIGHT LIGANDS FOR MODULATING HORMONE RECEPTORS

摘要

Disclosed herein are small molecule modulators hormone receptors, includi ng agonists and antagonists of luteinizing hormone/choriogonadotropin, folli cle stimulating hormone and thyroid stimulating hormone receptors. Exemplary disclosed compounds include those of the formula wherein X is -S(O)nR5; n i s 0, 1 or 2; Y is -OR6 or -NR7R8 R1 and R2 independently are selected from o ptionally substituted lower aliphatic, alkoxy, aralkyl, halogen, H and -OR5, wherein R5 is selected from lower alkyl, H, aralkyl, acyl, alkoxycarbonyl a nd aminocarbonyl; R3 and R4 independently are selected from acyl, alkoxycarb onyl, aminocarbonyl, aralkyl, H, lower alkyl and cycloalkyl; R5 is selected from lower alkyl, aralkyl, cycloalkyl and haloalkyl; R6 is selected from H, lower alkyl and aralkyl; R7 and R8 independently are selected from H, lower alkyl, aralkyl and cycloalkyl.