| 摘要 |
The bacterial protein OpuCA, an intracellular part of an ABC transporter, has been shown to interact directly with TRAP. The present invention provid es methods and compositions directed at interfering with the interaction bet ween OpuCA and TRAP. The resulting inhibition of TRAP advantageously will re duce pathogenesis of all bacteria that utilize this pathway. The present inv ention further provides methods and compositions directed at interfering wit h the interaction between TRAP and the extracellular substrate binding prote in OpuCC, or the membrane-associated proteins OpuCB and OpuCD, which, like O puCA, are encoded by the bacterial OpuC operon. Accordingly, the present met hods and compositions will be useful in treating diseases caused by such bac teria.
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