| 发明名称 |
Tripeptide prodrug compounds |
| 摘要 |
The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide of three amino acids, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by a trouase enzyme such as Thimet oligopeptidase. Also disclosed are methods of making and using the prodrug compounds.
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| 申请公布号 |
US2007275903(A1) |
申请公布日期 |
2007.11.29 |
| 申请号 |
US20070728771 |
申请日期 |
2007.03.27 |
| 申请人 |
MEDAREX, INC. |
发明人 |
BEBBINGTON CHRISTOPHER R.;DUBOIS VINCENT;GANGWAR SANJEEV;LOBL THOMAS J.;NIEDER MATTHEW H.;PICKFORD LESLEY B.;TROUET ANDRE;YARRANTON GEOFFREY T. |
| 分类号 |
C07K5/00;A61K31/704;A61K38/00;A61K38/06;A61K47/48;A61P29/00;A61P31/00;A61P35/00;A61P43/00;C07K5/02;C07K5/08;C07K5/083;C07K5/087;C07K7/00 |
主分类号 |
C07K5/00 |
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