发明名称 |
36 -DES (3 -METHOXY-4 -HYDROXYCYCLOHEXYL) 36 - (3 -HYDROXYCYCLOHEPTYL) DERIVATIVES OF RAPAMYCIN FOR THE TREATMENT OF CANCER AND OTHER DISORDERS |
摘要 |
<p>The present invention relates to novel 36-des(3-methoxy-4-hydroxycyclohexyl)-36-(3-hydroxycycloheptyl)rapamycin derivatives, methods for their production, and uses thereof. In a further aspect the present invention provides for the use of these 36-des(3-methoxy-4-hydroxycyclohexyl)-36-(3-hydroxycycloheptyl)rapamycin derivatives in the treatment of cancer and / or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft: vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.</p> |
申请公布号 |
WO2007135397(A1) |
申请公布日期 |
2007.11.29 |
申请号 |
WO2007GB01856 |
申请日期 |
2007.05.18 |
申请人 |
BIOTICA TECHNOLOGY LIMITED;WILKINSON, BARRIE;ZHANG, MING-QIANG;SHERIDAN, ROSE, MARY;BECKMANN, CHRISTOPH |
发明人 |
WILKINSON, BARRIE;ZHANG, MING-QIANG;SHERIDAN, ROSE, MARY;BECKMANN, CHRISTOPH |
分类号 |
C07D493/18;A61K31/496;A61P35/00 |
主分类号 |
C07D493/18 |
代理机构 |
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代理人 |
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地址 |
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