| 摘要 |
The present invention provides a three-dimensional non-spherical micro-scaffold for cell culture and delivery. The micro-scaffold is prepared using a biocompatible polymer selected from the group consisting of PLA, PLLA, PGA, PGLA, PCL, chitosan, polylactides, polyglycolides, epsilon-caprolactone, polyhydroxyvaleric acid, polyhydroxybutyric acid, other polyhydroxy acids, polytrimethylene carbonate, polyamines, vinyl polymers, polyacrylic acids and their derivatives containing ester, polyethylene glycols, polydioxanones, polycarbonates, polyacetals, polyorthoesters, polyamino acids, polyphosphoesters, polyesteramides, polyfumerates, polyanhydrides, polycyanoacrylates, polyoxamers, polyurethanes, polyphosphazenes, aliphatic polyesters, poly(amino acid), copoly(ether-ester), polyakylene oxalate, polyamides, poly(iminocarbonate), polyoxaester, polyamidoesters, amine group-containing polyoxaester, polyacetal, polyalkanoate, gelatin, collagen, elastine, polysaccharide, alginate, chitin, hyaluronic acid, and combinations thereof, as a biocompatible polymer for use in the in vitro culture and in vivo injection of adult stem cells, by a RP (rapid prototyping) system with a spry nozzle. The three-dimensional micro-scaffold have a Moebius strip-shaped, twisted band or twisted tubular structure, which has a one or two or more twists, such that one side of the strip is connected to the other side in an upside-down manner without intermittence, and thus there is no distinction between the inside and outside surfaces. Alternatively, the structure has a Klein bottle- or Klein jar-like twisted bottle or twisted tubular structure, in which the inlet and outlet of the structure meet each other through a surface of the outer wall of the structure, so that the inlet and the outlet are one and the same. |
