ENTEROSTATIN AS THERAPEUTIC AGENT FOR HYPOGLYCEMIA
摘要
It has been discovered that enterostatin injections into mice caused an increase in blood glucose levels within 15 minutes of injection, and the glucose levels remained high for up to an hour after injection. In addition, mice injected with enterostatin showed less of an initial decrease in blood glucose following an insulin injection. Enterostatin was also shown to decrease AMPK activity in both mice and human tissues, which is additional support that glucose production is increased after enterostatin injection. This ability to enhance glucose production indicates that enterostatin could be used to treat hypoglycemia.
申请公布号
WO2007101179(A3)
申请公布日期
2007.11.29
申请号
WO2007US62851
申请日期
2007.02.27
申请人
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE;YORK, DAVID, A.;PARK, MIEJUNG