OVR232V3 ANTIBODY COMPOSITIONS AND METHODS OF USE

摘要

The invention provides isolated anti-ovarian, colon, prostate, or lung cancer antigen (Ovr232v3) antibodies that bind to Ovr232v3 on a mammalian cell. The invention also encompasses compositions containing an anti-Ovr232v3 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr232v3 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr232v3 antibodies. The invention encompasses a method of producing the anti-Ovr232v3 antibodies. Other aspects of the invention are a method of killing an Ovr232v3-expressing cancer cell via contacting the cancer cell with an anti-Ovr232v3 antibody and a method of alleviating or treating an Ovr232v3 -expressing cancer in a mammal via administering a therapeutically effective amount of the anti-Ovr232v3 antibody to the mammal.