| 摘要 |
<P>PROBLEM TO BE SOLVED: To improve safety and durability of a biological tissue for transplantation after transplanted to a human being and to give a field for reproduction due to invasion of autologous cells by carrying out decellularization processing so as to make a biological tissue sampled from an animal nearly completely acellular. <P>SOLUTION: A cell removal solution in which a blood vessel tissue T held by a cell holding part 12 is immersed is given a flow nearly equivalent to a blood flow flowing through the inside of the main artery of a human body, and the whole periphery of the lateral side of the blood vessel tissue T is thoroughly irradiated with microwaves of a 2.45 GHz frequency and 800 W output while an irradiation apparatus 32 is rotated by the rotation of a table 31. Thus, the blood vessel tissue T sampled from the animal is made nearly completely acellular, and original cells are removed nearly completely at a DNA level to obtain a xenogenic tissue valve from which porcine endogenous retrovirus and α-galactose antigen are removed nearly completely. <P>COPYRIGHT: (C)2008,JPO&INPIT |
