| 摘要 |
The present inventors intravenously administered laboratory animals with molecules in which peptides and colloidal metal particles had been bound, to discover that the molecules translocated to the brain, specifically into cerebral neurons. Since activity to translocate into cerebral neurons could not be observed when the metal colloids were not bound, this activity was suggested to be a property of the colloidal metal particles. Desired compounds can be translocated into cerebral neurons by binding them to the colloidal metal particles. Furthermore, by using as carriers conjugate molecules in which peptides having brain-localizing activity are bound to the colloidal metal particles of the present invention, desired compounds can be delivered into cerebral neurons by intravenous administration.
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