PREPARATION AND STORAGE OF STABLE, BIOLOGICALLY ACTIVE MATERIALS

摘要

A method for the preparation of biologically active materials is presented. The invention involves taking a base material such as allografts, xenografts, polymers, metals, and ceramics and combining it with a biologically active agent, such as proteins, cytokines, growth factors, and enzymes after which it is irradiated with ionizing radiation to sterilize and stabilize the material. The resulting biologically active material may then be stored at ambient temperature while maintaining its biological activity and the structural integrity of the base material. The invention is particularly useful for eliciting desired biological responses in human and animal medicine, and in certain industrial applications.